What is OrCel®

Product Description
OrCel® is a bilayered cellular matrix in which normal human allogeneic skin cells (epidermal keratinocytes and dermal fibroblasts) are cultured in two separate layers into a Type I bovine collagen sponge. Donor dermal fibroblasts are cultured on and within the porous sponge side of the collagen matrix while keratinocytes, from the same donor, are cultured on the coated, non-porous side of the collagen matrix.

OrCel® serves as an absorbable biocompatible matrix that provides a favorable environment for host cell migration and has been shown to contain the following cell-expressed cytokines and growth factors: FGF-1 (bFGF), NGF, GM-CSF, IL-1a, IL-1b, IL-6, HGF, KGF-1 (FGF-7), M-CSF, PDGF-AB, TGF-a, TGF-b1, TGF-b2, and VEGF. OrCel® is not intended to be a human skin replacement and does not contain Langerhans cells, melanocytes, macrophages, lymphocytes, blood vessels or hair follicles. DNA analysis performed on two OrCel® -treated donor site patient tissue samples showed no trace of allogeneic cell DNA after two or three weeks respectively.